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KMID : 0923620200200010006
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Immune Network
2020 Volume.20 No. 1 p.6 ~ p.6
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IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
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Kuen Da-Sol
Kim Byung-Seok
Chung Yeon-Seok
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Abstract
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IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8+ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or anti-tumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed.
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KEYWORD
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Tumor microenvironment, Th17 cells, Interleukin-17, T-lymphocytes
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